SALMONELLA IBD

Sinopsis

Salmonellae are important pathogens, responsible for an estimated one million deaths and 100 million human infections annually. Their genomes are mosaic puzzles - results of lateral transfer events that occur within a stable genetic background. Extraordinary diversity of host ranges and pathogenicity traits between different strains are the consequence of both specific genome insertions/deletions and minute changes in genome composition. Genomic information decoded from a multitude of differentáSalmonellaástrains and new dramatic insights into pathogenic processes emphasize the fact thatáSalmonellaresearch is currently at a very exciting juncture. In addition to their fascinating resilience in both the environment and eukaryotic hosts,áSalmonellaáprefers tumours over any other location within the human host (by a factor of 1000 or more). This ability could propeláSalmonellaáinto future use as a therapeutic delivery agent to control and/or cure cancers. In this book, internationally acclaimed experts review cutting-edge topics ináSalmonellaágenomics and molecular biology, providing a timely snapshot of the current state of research. Topics include latest approaches to sub-species level classification and phage typing ofáSalmonella, comparative genomics, the search for genetic determinants for survival of the bacterium in different environments and the evolution of niche specialization byáSalmonella. The book also explores the latest genomic information and molecular characterizations of sRNAs and complements of fimbriae, flagella and secreted virulence factors. Moreover,áS.áTyphi pathogenesis, interactions of the host with intracellularáSalmonellaáand the host',s anti-Salmonellaáimmune response are reviewed. The current knowledge onáSalmonellaábiofilm formation and a progress report on usingáSalmonellaáas an anti-tumour tool conclude this compendium. Essential reading for all researchers working witháSalmonellaáand related organisms, and recommended reading for other scientists working on bacterial genomics, molecular biology and bacterial molecular and cellular pathogenesis.